Adapting with Age

Adapting with Age

Introduction

  • Brain plasticity changes throughout a lifetime, not just something that happens all the time.
  • In the 1970s, psychologist Hans-Lukas Teuber studied brain damage in World War II soldiers.
  • Key finding: Younger soldiers recovered better from brain injuries than older ones.
  • This suggests that brain flexibility diminishes with age.

The Brain as a Changing Landscape

  • Young brains are like the Earth thousands of years ago: flexible, with borders that can shift.
  • As brains age, they settle into patterns, much like how country borders and constitutions stabilize over time.
  • Example: The American Constitution had 12 amendments in its first 13 years, but now changes occur much less frequently.
  • Silicon Valley startups are highly flexible, but as companies grow, they become rigid and bureaucratic—similar to brain development.

From Fluid to Crystallized Intelligence

  • Babies: Few built-in skills but immense flexibility.
  • Adults: Developed expertise at the expense of flexibility.
  • Trade-off: Young brains have fluid intelligence, whereas older brains develop crystallized intelligence.
  • Adults get better at certain skills but lose the ability to learn completely new ways of thinking easily.

Why Does Plasticity Decline?

1. Pruning of Neural Connections

  • Babies’ brains are massively interconnected.
  • At age 2, neurons have about 15,000 connections each.
  • Over time, unnecessary connections are pruned, keeping only the most useful pathways.
  • Example: EEG studies show that a baby’s brain responds to a sound with activity in both auditory and visual areas; adults’ brains localize this response to the auditory cortex only.
  • This pruning leads to efficiency but reduces flexibility.

2. Targeted Neuromodulation

  • Babies experience broad, widespread plasticity.
  • Adults undergo pointillist plasticity, meaning only small, specific areas of the brain change when necessary.
  • The neuromodulatory system (e.g., acetylcholine) narrows its impact over time, limiting broad-scale change.
  • Example: A child learning language absorbs all sounds, while an adult struggles with new phonemes.

The Concept of Sensitive Periods

  • Critical periods: Windows where certain abilities must be developed, or they become impossible later.
  • Examples:
  • Language acquisition: If children do not hear language before a certain age, they may never fully acquire it (e.g., Genie, the feral child).
  • Accent adaptation: Mila Kunis moved to the U.S. at 7 and lost her accent; Arnold Schwarzenegger moved at 21 and retained his.
  • Vision development: Children with misaligned eyes must receive treatment by age 6, or their visual cortex will never develop correctly.

The Role of Experience in Shaping the Brain

  • Plasticity follows the stability of incoming data:
  • Stable inputs (e.g., visual edges, phonemes, grammar) → The brain locks them in early.
  • Unstable inputs (e.g., social interactions, motor skills, object recognition) → The brain keeps them flexible for a longer time.
  • Different parts of the brain solidify at different rates:
  • Primary visual and auditory cortices: Lock down early.
  • Higher-order cognitive areas (e.g., object recognition, language comprehension): Remain flexible longer.
  • Motor learning: Stays plastic throughout life (e.g., learning to surf, ride a bike, or use new tools).

Adult Brain Plasticity

  • While plasticity declines, it never disappears completely.
  • Examples of adult brain plasticity:
  • Learning to juggle increases brain volume in relevant areas.
  • Black cab drivers in London develop larger hippocampi due to memorizing city streets.
  • The Religious Order Study showed that nuns with Alzheimer’s remained cognitively sharp due to lifelong mental and social engagement.

Maintaining Plasticity as We Age

  • Key principle: Engage in activities that challenge the brain.
  • Practical strategies:
  • Switch daily routines (e.g., wear your watch on the opposite wrist, brush your teeth with your non-dominant hand).
  • Rearrange furniture, paintings, or workspaces regularly.
  • Take different routes when commuting to introduce novelty.
  • Stay socially active—interacting with people is cognitively demanding.
  • Encourage elderly individuals to stay engaged in mentally challenging activities to maintain cognitive function.

Summary

  • Plasticity decreases with age, but not uniformly across the brain.
  • The brain prioritizes efficiency over flexibility, stabilizing useful pathways.
  • Some areas (e.g., primary sensory cortices) solidify early, while others (e.g., higher cognition) remain flexible.
  • New learning is always possible, but it requires effort and motivation.
  • Staying engaged in learning and social activities is crucial for lifelong cognitive health.
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